業績/Publication

原著論文/Original Article

15. Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A
Rei Yoshimoto, Daisuke Kaida*, Masaaki Furuno, A. Maxwell Burroughs, Shohei Noma, Harukazu Suzuki, Yumi Kawamura, Yoshihide Hayashizaki, Akila Mayeda and Minoru Yoshida* (*: Co-Corresponding Author)
RNA, 23, 47-57 (2017) [Pubmed]

 

14. Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest
Takayuki Satoh and Daisuke Kaida* (*: Corresponding Author)
Scientific Reports, 6, 27829 (2016) [Pubmed]

 

13. RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis
Hideaki Kakeya, Daisuke Kaida, Hiromi Sekiya, Koji Nagai, Minoru Yoshida and Hiroyuki Osada
J Antibiot (Tokyo),  69, 121-123 (2016) [Pubmed]

 

12. Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD
Mitsunori Koga, Megumi Hayashi and Daisuke Kaida* (*: Corresponding Author)
Nucleic Acids Research, 43, 8258-8267 (2015)  [Pubmed]

 

11. Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins
Yanqi Hao, Recep Colak, Joan Teyra, Carles Corbi-Verge, Alexander Ignatchenko, Hannes Hahne, Mathias Wilhelm, Bernhard Kuster, Pascal Braun, Daisuke Kaida, Thomas Kislinger and Philip M. Kim
Cell Reports, 12, 183-189 (2015)  [Pubmed]

 

10. Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein
So Masaki, Rei Yoshimoto, Daisuke Kaida, Asuka Hata, Takayuki Satoh, Mutsuhito Ohno and Naoyuki Kataoka
Int. J. Mol. Sci., 16, 3705-3721 (2015)  [Pubmed]

 

9. U2 snRNP Is Required for Expression of the 3′ End of Genes
Mitsunori Koga, Takayuki Satoh, Ichiro Takasaki, Yumi Kawamura, Minoru Yoshida and Daisuke Kaida*
(*: Corresponding Author)
PLOS ONE, 9(5), e98015 (2014)  [Pubmed]

 

8. U1 snRNP Determines mRNA Length and Regulates Isoform Expression
Michael G. Berg, Larry N. Singh, Ihab Younis, Qiang Liu, Anna Maria Pinto, Daisuke Kaida, Zhenxi Zhang, Sungchan Cho, Scott Sherrill-Mix, Lili Wan and Gideon Dreyfuss
Cell, 150, 53-64 (2012)  [Pubmed]

 

7. U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
Daisuke Kaida, Michael G. Berg, Ihab Younis, Mumtaz Kasim, Larry N. Singh, Lili Wan and Gideon Dreyfuss
Nature, 468(7324), 664-668 (2010)  [Pubmed]

 

6. Rapid-Response Splicing Reporter Screens Identify Differential Regulators of Constitutive and Alternative Splicing
Ihab Younis, Michael Berg, Daisuke Kaida, Kimberly Dittmar, Congli Wang and Gideon Dreyfuss
Mol. Cell. Biol., 30 1718-1728 (2010)  [Pubmed]

 

5. Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast
Chor-Wai Lo, Daisuke Kaida, Shinichi Nishimura, Akihisa Matsuyama, Yoko Yashiroda, Hiroshi Taoka, Ken Ishigami, Hidenori Watanabe, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi and Minoru Yoshida
Biochem. Biophys. Res. Commun., 364, 573-577 (2007)  [Pubmed]

 

4. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi and Minoru Yoshida
Nature Chemical Biology, 3, 576-583 (2007)  [Pubmed]

 

3. Rsp5-Bul1/2 Complex Is Necessary for the HSE-mediated Gene Expression in Budding Yeast
Daisuke Kaida, Akio Toh-e and Yoshiko Kikuchi
Biochem. Biophys. Res. Commun., 306, 1037-1041 (2003)  [Pubmed]

 

2. Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression
Daisuke Kaida, Hideki Yashiroda, Akio Toh-e and Yoshiko Kikuchi
Genes to Cells, 7, 543-552 (2002)  [Pubmed]

 

1. The PY-motif of Bul1 protein is essential for growth of Saccaromyces cerevisiae under various stress conditions
Hideki Yashiroda, Daisuke Kaida, Akio Toh-e and Yoshiko Kikuchi
Gene, 225, 39-46 (1998)  [Pubmed]

 

 

総説/Review

3. The reciprocal regulation between splicing and 3′-end processing
Daisuke Kaida
Wiley Interdisciplinary Reviews: RNA, Published online, [Pubmed]

 

2. Splicing in Oncogenesis and Tumor Suppression
Daisuke Kaida, Tilman Schneider-Poetsch and Minoru Yoshida
Cancer Science, 103, 1611-1616 (2012)  [Pubmed]

 

1. Garbled Messages and Corrupted Translations
Tilman Schneider-Poetsch, Takeo Usui, Daisuke Kaida and Minoru Yoshida
Nature Chemical Biology, 6, 189-198 (2010)  [Pubmed]

 

 

総説、著書(日本語)/Review in Japanese

7. snRNA
甲斐田大輔
ノンコーディングRNA 廣瀬哲郎 泊幸秀 編 28-37 (2016) 化学同人

 

6. U snRNPによる遺伝子発現制御
甲斐田大輔
実験医学, 31, 1093-1098 (2013)

 

5. スプライソソームのスプライシング以外の機能
甲斐田大輔
生化学, 84, 562-565 (2012)

 

4. mRNAスプライシングを制御することで筋ジストロフィーを治療する
甲斐田大輔
ファルマシア, 48, 59 (2012)

 

3. タイリングアレイによるmRNA解析
甲斐田大輔
臨床検査, 55, 854-857 (2011)

 

2. 新たな分子標的としてのスプライシング反応とその阻害剤
甲斐田大輔、吉田稔
がんの分子標的治療 鶴尾隆 編 325-331 (2008) 南山堂

 

1. スプライシング阻害剤の発見と創薬への期待
小竹良彦、甲斐田大輔、水井佳治、吉田稔
蛋白質 核酸 酵素, 53, 28-35 (2008)

 

 

その他/Others

2. U1 snRNPはmRNA前駆体を異常な切断とポリA化から保護する
甲斐田大輔
ライフサイエンス 新着論文レビュー

 

1. ラボレポート「三人寄れば文殊の知恵」
甲斐田大輔
実験医学, 28, 2680-2682 (2010)